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Health and Human Services (NIH, ARPA-H, CDC…): open SBIR/STTR topics

HHS topics come from NIH institutes, CDC, ARPA-H and other HHS components. Many NIH opportunities are omnibus or targeted funding announcements.

Sorted by deadline. Data from SBIR.gov; refreshed Oct 13, 2026 2:47 AM PT.

NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)

Closes Apr 6, 2027 · 175d leftHealth and Human Services (NIH, ARPA-H, CDC…) · NIHSBIRPA-27-101

Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S.

NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)

Closes Apr 6, 2027 · 175d leftHealth and Human Services (NIH, ARPA-H, CDC…)STTRPA-27-102

Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S.

NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)

Closes Apr 6, 2027 · 175d leftHealth and Human Services (NIH, ARPA-H, CDC…)SBIRPA-27-100

Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S.

SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)

Closes Apr 6, 2027 · 175d leftHealth and Human Services (NIH, ARPA-H, CDC…)SBIRPAR-27-098

The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S.

ARPA-H Lineage Topic

Closes Sep 30, 2027 · 352d leftHealth and Human Services (NIH, ARPA-H, CDC…) · ARPA-HARPA-H 05

he purpose of this topic supports the advancement, commercialization, and translation of technologies that originated from ARPA-H funded efforts.

Breaking Ground: The First Curative, Durable, Non-Surgical Therapy for Endometriosis

Closes Sep 30, 2027 · 352d leftHealth and Human Services (NIH, ARPA-H, CDC…) · ARPA-HARPA-H 04

The purpose of this topic aims to develop treatments for endometriosis that are non-surgical.

Development of an annual test to inform women about their future fertility

Closes Sep 30, 2027 · 352d leftHealth and Human Services (NIH, ARPA-H, CDC…) · ARPA-HARPA-H 01

Development of an annual test to inform women about their future fertility - The purpose of this topic is to discover new biomarkers that provide women with actionable data for fertility planning.

Rapid Comprehensive Diagnostic Test for Multi-System Autoimmune Disease

Closes Sep 30, 2027 · 352d leftHealth and Human Services (NIH, ARPA-H, CDC…) · ARPA-HARPA-H 06

The purpose of this topic is to spur the development of novel, rapid diagnostic assays for multi-system autoimmune disease, which represents an unmet healthcare need.

Universal Platform for Living Adaptive Toxin-removal (UNI-PLAT)

Closes Sep 30, 2027 · 352d leftHealth and Human Services (NIH, ARPA-H, CDC…) · ARPA-HARPA-H 03

The purpose of this topic area is to catalyze the development of a universal, “plug-and-play” synthetic biology platform that enables next-generation microbial chassis capable of performing a broad array of programmable functions.

Versatile Bioadhesives

Closes Sep 30, 2027 · 352d leftHealth and Human Services (NIH, ARPA-H, CDC…) · ARPA-HARPA-H 02

The purpose of this topic is to develop next-generation bioadhesive platforms that can safely and reliably seal, bond, and repair a wide range of tissues in challenging clinical conditions, including wet, bloody, and mechanically dynamic environments.

Virtual Human Brain for the Development of Neurosurgical Robotics

Closes Sep 30, 2027 · 352d leftHealth and Human Services (NIH, ARPA-H, CDC…) · ARPA-HARPA-H 07

The purpose of this topic aims to take a first step toward AI-assisted intracranial microsurgery by creating a high-resolution, physically and anatomically accurate virtual human brain.

Other agencies: NSF · DOW · EPA