National Science Foundation: open SBIR/STTR topics
NSF funds SBIR/STTR through America's Seed Fund. Topics are broad technology areas and proposals are generally preceded by a Project Pitch.
- 268 open or upcoming topics
- Next deadline: Jul 7, 2027
- Programs: —
Sorted by deadline. Data from SBIR.gov; refreshed Oct 13, 2026 2:47 AM PT.
Accessible and Inclusive AR/VR/MR
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Advanced Engineering Materials
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Advanced Inclusive Learning Technologies
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Advanced Manufacturing
The Advanced Manufacturing topic aims to support emerging innovations in manufacturing with the potential to stimulate the nation's manufacturing sector by improving efficiency, competitiveness and sustainability.
Advanced Materials
The Advanced Materials topic addresses the development of new and improved materials for a wide variety of commercial and industrial applications.
Advanced Metrology and Sensors
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Advanced Nuclear Energy Tech
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Advanced Optical Components and Systems
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Advanced Systems for Scalable Analytics
The Advanced Systems for Scalable Analytics topic focuses on innovations needed for building systems that organize and process large and ever-increasing volumes of structured, semi-structured and unstructured data to reveal actionable new insights.
Agricultural Technologies
The Agricultural Technologies topic supports innovations enabling farm production ecosystems that support the proper utilization of natural resources.
Agroforestry
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Algorithms and Applications
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Animal Biotechnology
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Aquaculture
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Artificial Intelligence
The Artificial Intelligence topic focuses on cutting-edge technologies in the field of deep learning-based AI systems and AI-based hardware.
Assistive, Enabling and Rehabilitative technologies
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Augmented Virtual and Mixed Reality
The Augmented Virtual and Mixed Reality (AR/VR/MR) topic focuses on advancing immersive technological experiences for humans grounded in research.
Autonomous Systems and Economies, and Smart Contracts
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Aviation
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Behavioral Transitions
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Bio-Inspired Technologies
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Biochemicals
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Bioinstruments and Biosensors
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Biological Technologies
The Biological Technologies topic covers a wide range of technology areas to advance engineering and science innovation across the biological spectrum.
Biomedical Technologies
The Biomedical Technologies topic aims to support the early-stage development of novel products, processes or services that will enable the delivery of high-quality, economically efficient healthcare.
Blockchain, DAGs, and Next-Gen Protocols
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Building Analytical System for Learning from Dynamic Environments
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Building and Infrastructure
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CO2 and Methane Conversion, Petrochemicals, Oil and Gas
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Carbon Sequestration
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Catalysts, Advanced Chemicals and Materials
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Cell and Tissue Engineering
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Chemical Technologies
The Chemical Technologies topic covers a wide range of technology areas of current and emerging commercial significance to many areas, including the broad chemical industry; food processing and technology; agrochemicals; chemical alternatives and organics; green chemicals; water treatment and separations; advanced catalysts and materials; and biochemicals.
Chemical and Environmental Sensing and Data
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Climate Change Adaptation, Mitigation and Reversal
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Cloud and High-Performance Computing
The Cloud and High-Performance Computing (HPC) topic focuses on innovations that result in substantial improvements to cloud computing or high-performance computing platforms.
Coatings and Surface Modifications
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Cognitive Science-based Technologies
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Communication and Networking Technologies
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Communications, Information, and Data Storage
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Computation on Encrypted Data
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Computational Architecture
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Computer Vision Based AI Technologies
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Convergence of AI and Cloud/HPC
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Convergence with Big Data, and Artificial Intelligence
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Convergence with Internet of Things, Crowdsourcing and Crowdsensing
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Conversational AI Technologies
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Cryptography, Security, and Cybersecurity
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Cryptography, including Post-quantum Cryptography
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Cybermanufacturing
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Cybersecurity and Authentication
The Cybersecurity and Authentication topic focuses on innovations related to the security and integrity of data and data processing and the authentication of people and devices.
Data Mining, Machine Learning (Non-deep learning-based), and Reinforcement Learning
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Data Privacy and Integrity
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Data and communication
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Decision Support and Optimization
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Device Authentication
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Diagnostics
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Digital Assets
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Digital Ecosystem for the Environment
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Digital Health
The Digital Health topic aims to support the early-stage development of novel devices, components, systems, algorithms, networks, applications or services that will enable the transformation of healthcare from reactive, hospital-centered and indemnity-based to proactive, person-centered, preventive and cost-efficient.
Directed Energy
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Distributed Consensus and Fault Tolerance Mechanisms
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Distributed Ledger
The Distributed Ledger topic area covers a wide range of technology areas of current and emerging commercial significance and impact spanning all areas of distributed ledgers, including blockchains, directed acyclic graphs (DAGs) and related capabilities (cryptography, smart contracts, etc.).
Distributed Ledger
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Distributed Ledger Interoperability
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Distributed Ledger in Edge and Cloud Computing
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Distributed Ledger in Network Architecture and Management
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Distributed Manufacturing
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Drug Delivery Methods
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Drug Discovery
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Ecomanufacturing
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Edge Computing
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Electromagnetics
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Electronic Devices
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Electronic Materials
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Emission or Waste Reduction and the Circular Economy
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Encryption, including Homomorphic Encryption
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Energy Efficiencies and Data Technologies
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Energy Efficiency and Sustainability
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Energy Harvesting Devices and Systems
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Energy Production and Power Generation
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Energy Storage
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Energy Technologies
The Energy Technologies topic covers new energy sources and resources, power generation, energy storage and electronic systems for energy sources used in mobile technologies and off-grid applications.
Enhanced UI/UX for Immersive AR/VR/MR
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Environmental Technologies
Environmental Technologies cover a range of innovations focused on sustainability, high commercial impacts and societal and environmental benefits.
Environmental Technologies for Achieving Sustainable Development
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Environmental and Societal Impact Measurement
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Environmentally Sustainable Solutions for AR/VR/MR Design
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Ethical AI Frameworks for Advancing Education
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Farming in Underserved Communities
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Fermentation
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Financial Technologies
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Food Processing, Chemicals and Agriculture
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Food Waste Mitigation
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Food, Regenerative Agriculture, and Energy
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Fusion
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General Medical Devices
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Green Chemicals and Chemical Alternatives
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HCI to Enhance Human Cognitive Capacity
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Habitat Conservation, Adaptation and Restoration
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Harvesting Complex Systems
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Health and Biomedical informatics
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Health in Underserved Communities
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Health in Underserved Communities
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Healthcare Workflow, Economics and Delivery
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Human Assistive Technologies and Bio-related Robotics
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Human viability and sustainability
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Human-Centric AR/VR/MR Analytics for Collaboration
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Human-Computer Interaction
The Human-Computer Interaction (HCI) topic aims to bridge the gap between research-based innovation and practical applications by catalyzing high-risk advancements rooted in research.
Human-Machine Interfaces and Control/Architecture
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Human-to-Technology Interfaces and Decentralized Applications (dApps)
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Hydrogen Technologies
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Hypersonic
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Immersive AR/VR/MR Fostering Shared Experiences
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Implantables or Procedures
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Improved Resilience through Interspecies Interchange
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In space services and production
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In-memory Processing
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Infrastructure and Flow
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Instrumentation and Hardware Systems
The Instrumentation and Hardware Systems topic addresses the research and development of new and improved instrumentation and related systems for a wide variety of commercial and industrial applications.
Instrumentation or Hardware Systems for Actuation, Control, and Manipulation
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Instrumentation or Hardware Systems for Detection and Characterization
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Instrumentation or Hardware Systems for Imaging
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Integrated Circuit Design
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Interconnects
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Internet of Things
The Internet of Things (IoT) is a rapidly evolving field that involves the interconnection and interaction of smart objects (objects or devices with embedded sensors, onboard data processing capability, and a means of communication) to provide automated services that would otherwise not be possible.
IoT Communications
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IoT Integrated Systems
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IoT Sensors and Actuators
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Knowledge and Data Management Technologies
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Language-Based AI Technologies
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Launch vehicles and propulsion
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Learning and Cognition Technologies
Innovative approaches to learning and cognition development leverage groundbreaking technological advancements rooted in research.
Life Science Research Tools
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Lighting and Displays
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Marine
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Marketplaces for Data and Models
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Materials and Devices for Power Electronics
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Materials and Devices for Thermal Management
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Materials for Biomedical Applications
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Materials, Processes, Prototyping Methods or Enablers
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Medical Devices
The Medical Devices topic aims to develop novel medical device platforms, introduce innovative medical technologies or translate emerging scientific principles into health practice.
Medical Diagnostics and Devices
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Medical Imaging
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Metals and Ceramics
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Microbiome and Microbial Diversity
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Microelectronics Packaging and Systems Integration
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Middleware
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Mobility
The Mobility topic encourages novel innovations in the land, air, and sea-based movement of goods and people that improve sustainability and resiliency.
Modeling and Simulation
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Monitoring Devices
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Monitoring or Instrumentation
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Nanotechnology
The Nanotechnology topic addresses the creation and manipulation of functional materials, devices and systems with novel properties that are achieved through the control of matter at a submicroscopic scale (from a fraction of nanometer to about 100 nanometers).
Nanotechnology
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Natural Resources and Critical Minerals
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Nature-based Solutions
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Network and Device Security
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Networked Sensors and Sensing
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Networking
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Neuroadaptive Systems
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Novel AI Hardware Technologies (e.g.: Neuromorphic Computing, High-performance Technologies for AI, Smart and Secure Edge Devices, etc.)
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Novel Advanced Materials-based Sensors
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Novel Power and Thermal Management Sensors
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Novel Semiconductor-based Sensors
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Novel Visualization Technologies
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Other Advanced Materials Technologies
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Other Agricultural Technologies
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Other Augmented Virtual and Mixed Reality Technologies
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Other Biological Technologies
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Other Biomedical Technologies
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Other Chemical Technologies
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Other Cloud and High-Performance Computing Technologies
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Other Cybersecurity and Authentication Technologies
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Other Digital Health Technologies
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Other Distributed Ledger Technologies
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Other Energy Technologies
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Other Environmental Technologies
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Other Human-Computer Interaction Technologies
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Other Instrumentation or Hardware Systems Technologies
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Other IoT Technologies
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Other Learning and Cognition Technologies
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Other Manufacturing Technologies
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Other Mobility Topics
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Other Novel Technologies
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Other Novel Technologies
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Other Pharmaceutical Technologies
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Other Photonics Technologies
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Other Power Management Technologies
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Other Quantum Information Technologies
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Other Robotics Technologies
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Other Semiconductor Technologies
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Other Space-related Technologies
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Other Topics
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Other Topics
For projects that do not seem to fit into one of the other technology topic areas, but still meet the NSF SBIR/STTR goals of supporting research and development of deep technology with commercial viability and the potential to benefit society, please pick Other Topics and subtopic OT1.
Other Wireless Technologies
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Performance Monitoring
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Personal Authentication
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Personal Transportation
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Pharmaceutical Technologies
The Pharmaceutical Technologies topic covers a wide range of technology areas that advance the discovery, formulation, and manufacture of novel drugs, moieties, compounds, products, processes, platforms or services that will improve the selection, quality or price of pharmaceutical and biologic therapies.
Pharmaceutical and Biologic Manufacturing
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Photonic Devices
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Photonic Energy Conversion
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Photonic Materials
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Photonic Metamaterials and Plasmonics
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Photonics
The Photonics topic addresses the research and development of new materials, devices, components, and systems that have the potential for revolutionary change in the optics and photonics industries.
Physical, Mental and Behavioral Health
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Plant Biotechnology
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Polyculture Systems
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Power Electronics Circuits and Control Systems
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Power Management
The Power Management topic address the development of novel technologies that enable new power and thermal management solutions.
Power Management Infrastructure and Smart Grid Systems
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Precision Agriculture
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Processing and Metrology Technology
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Processing on Encrypted Data
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Processor Architecture and Design
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Quantum Algorithms
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Quantum Communications
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Quantum Computing
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Quantum Device Manufacturing
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Quantum Information Technologies
This topic focuses on innovations in information and communications technologies that rely fundamentally on quantum mechanical properties and interactions.
Quantum Optics and Nanophotonics
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Quantum Sensing and Metrology
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Quantum Simulation
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Rehabilitation
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Renewable Energy Generation & Storage
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Research-based Design for Behavioral Health
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Resilience and Resource Management
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Resiliency and Sustainability
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Resilient Supply & Distribution
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Robotic Applications
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Robotics
The Robotics topic covers robot intelligence and experiential learning, particularly in the areas of high-performance processors or hardware that provides situational awareness and improved artificial intelligence.
Robotics in Agile Manufacturing, and Co-Robots
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Satellite technology
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Scalability Solutions and Accumulators
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Secure Machine-to-Machine Communication
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Secure and Trusted Computing
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Security of Cloud and High Performance Computing (HPC) Platforms
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Semiconductors
The Semiconductors topic addresses the research and development of new designs, materials, devices and manufacturing systems that have the potential for impactful change in the semiconductor and microelectronics industry.
Separations and Water Treatment
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Silicon Photonics and Photonic Integrated Circuits
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Smart Integrated Systems
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Social and Behavioral Science Based Environmental Technologies
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Software Technologies for Scalable Analytical Systems
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Space
The Space topic seeks transformative technologies to create solutions for sustainable space exploration, habitation or industrialization that could also have a positive impact on human lives.
Space Transportation and Access
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Spaceflight infrastructure
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Structural and Infrastructural Materials
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Sustainable AI Technologies for Low Resource Environments
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Sustainable Chemical Manufacturing
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Sustainable Community Systems
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Sustainable Education Models for Future Generations
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Sustainable HCI Technologies
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Sustainable Semiconductor Manufacturing
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Synthetic Biology and Metabolic Engineering
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Systems for Thermal Management
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Technologies for Trustworthy AI (safe, fair, transparent, privacy-preserving, explainable, and/or secure)
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Telecommunications Technologies
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Tools for Critical Information Analysis to Broaden Engagement
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Trusted Identity and Identity Management
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Underground or Underwater Robotics for Low-Visibility, Poor-Connectivity or Hidden Topography
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Water Treatment, Resilience, and Sanitation
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Wearables and External Sensors
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Wide Bandgap Power Devices and Materials
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Wireless Devices and Components
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Wireless Systems
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Wireless Technologies
The Wireless topic involves next-generation wireless communication technologies requiring systems with high data rates, low costs and that support a wide variety of applications and services while maintaining full mobility, minimum latency, and long battery life.
Women's Health
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Women's Health
SBIR.gov lists this topic without a description. Open the official solicitation for the full scope.
Other agencies: DOW · HHS · EPA
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